Omics and Immunity Collective - Zhang Lab
Commitment to the Cure.
Deep Learning from Rare Diseases - Unlock Insights.
Passion for Decoding Mycobiology.
Research Highlights
Translational Immunotherapy Pipeline
Targeting integrin CD11b with carbohydrate PAMPs:
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A plant-derived pathogen-Associated Molecular Pattern (PAMP) molecule targeting novel epitopes on CD11b in inflammatory monocytes
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Induce trained immunity via calcium signaling-driven post-translational modification (PTM) changes, promoting cell differentiation into dendritic cells.
Adjuvant therapies:
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Developing a pipeline of innate immune engagers, including carbohydrate PAMPs and monoclonal antibodies targeting CD11b epitopes.
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Designed to enhance current immunotherapy efficacy and reduced adverse effect.
Preclinical development:
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Carbohydrate PAMP therapeutics have received FDA orphan drug designation.
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Currently undergoing safety and efficacy targeting in dogs with Spontaneous tumors.
Funding
Major Federal Grants:
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DoD - PRCRP Impact Award ($1.61 Million), 2021-2025, PI: Mei Zhang
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DoD - Rare Cancers Science Award ($2.2 million), 2024-2028, PI: Mei Zhang
Institutional and Collaborative Support ($750 k), PI: Mei Zhang
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CAHH Innovation Fund
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Case Immunology Transdisciplinary Scientific Initiative
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Case-Coulter Translational Research Collaborative (CCTRP)
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Third Ohio Frontier Translational Science Award (CTP)
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GI SPORE Career Development Award
Multi-Omics Explorer - Decoding Metabolite Dynamics in Skin Fungus
Investigate the interplay between post-translational modification, metabolite alterations, and their impact on macrophage polarization - Linking Malassezia metabolism to health solutions.
Focus Areas:
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Metabolite Alterations and Environmental Triggers
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Genetic and Epigenetic Drivers
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Macrophage polarization
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Health implications: Wound healing, neurological health, aging, autoimmune disease and cancer.
Approach:
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Employ an integrated approach across metabolomics, proteomics, genomics, and transcriptomics to investigate how environmental and biological factors drive metabolic shifts and their downstream effects.
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Deep learning from unique cases to redefine our understanding of skin Malassezia's role in health and disease, driving innovative therapies.
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Activate IRB protocols - unraveling the tryptophan-metabolite pathway in Malassezia with focus on populations with rare food allergies.
Data Stories
We develop workflows, analytical platforms, and data management system to transform complex datasets into actionable insights.
Focus Areas: Integrating multi-omics approach with advanced analytics, we uncover meaningful patterns and drive discoveries in immunology, microbiology, and translational medicine. ​
Deep learning to Unlock Insights
